Title of article
Cyclic urea HIV protease inhibitors containing alkynyl- and alkenyl-tethered heterocycles in the P2 region
Author/Authors
Scott L. Dax، نويسنده , , Stacy C. Cook، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
6
From page
797
To page
802
Abstract
A series of cyclic urea HIV protease inhibitors containing alkynyl-and alkenyl-tethered heterocycles in the P2 region were synthesized. The alkynyl compounds exhibited poor activity against the HIV protease enzyme. However, reduction of the triple bond afforded trans-alkenyl derivatives (XU348 and XU430) which displayed superb potency (sub-nanomolar Ki).
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788003
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