Title of article
Synthesis and in vitro cytotoxicity of cryptophycins and related analogs
Author/Authors
Jean-Marc de Muys، نويسنده , , Rabindra Rej، نويسنده , , Dieu Nguyen، نويسنده , , Brian Go، نويسنده , , Samuel Fortin، نويسنده , , Jean-François Lavallée، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
6
From page
1111
To page
1116
Abstract
Several members of the Cryptophycin family were synthesised using a straightforward convergent approach. The proposed synthetic route was used to prepare novel analogs of Cryptophycins A and B in which the benzylic epoxide moiety was replaced by alternate electrophilic functions. The effect of these modifications on cytotoxic activity was determined on several tumor cell lines.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788069
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