Title of article
Novel benzimidazole-4-carboxylic acid derivatives as potent and selective 5-HT3 receptor ligands
Author/Authors
Mar?a L. L?pez-Rodr?guez، نويسنده , , Ma José Morcillo، نويسنده , , Bellinda Benhamu، نويسنده , , Ma Dolores Riaguas، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
4
From page
1195
To page
1198
Abstract
A series of benzimidazole-4-carboxylic acid derivatives was synthesized and evaluated for affinity at 5-HT3 and 5-HT4 serotoninergic receptors. Compounds 1b, c and j exhibited high affinity for the 5-HT3 receptors (Ki=6.1, 3.7 and 4.9 nM, respectively) and no significant affinity for 5-HT4 (Ki>1000 nM) and 5-HT1A (Ki>10 000 nM) sites. Preliminary studies showed that 1c displayed activity in the two-compartment behavioural model.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788086
Link To Document