Title of article
Novel 2,5-disubstituted-1H-pyrroles with high affinity for the dopamine D3 receptor
Author/Authors
David Bolton، نويسنده , , Izzy Boyfield، نويسنده , , Martyn C. Coldwell، نويسنده , , Michael S. Hadley، نويسنده , , Maureen A. M. Healy، نويسنده , , Christopher N. Johnson، نويسنده , , Roger E. Markwell، نويسنده , , David J. Nash، نويسنده , , Graham J. Riley، نويسنده , , Geoffrey Stemp، نويسنده , , Harry J. Wadsworth، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
4
From page
1233
To page
1236
Abstract
A series of 2,5-disubstituted-1H-pyrroles (4–18) has been prepared based on replacement of the amide of sultopride 1 by a pyrrole ring. Subsequent modification of the basic side chain gave compounds with high affinity for the dopamine D3 receptor. In addition, 12 and 17 were shown to be D3 antagonists with 30-fold selectivity for the D3 receptor over the D2 receptor.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788093
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