Title of article
Structure-activity relationship of novel tallimustine derivatives: synthesis and antitumor activity
Author/Authors
Pier Giovanni Baraldi، نويسنده , , Italo Beria، نويسنده , , Barbara Cacciari، نويسنده , , Laura Capolongo، نويسنده , , Paolo Cozzi، نويسنده , , Nicola Mongelli، نويسنده , , Romeo Romagnoli، نويسنده , , Giampiero Spalluto، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
6
From page
1247
To page
1252
Abstract
Oligopeptide-like derivatives structurally related to the antitumor agent tallimustine, where one or two pyrrole rings were replaced by pyrazole or thiazole rings and bearing benzoyl nitrogen mustard or bromoacryloyl moieties were synthesized and evaluated in vitro and in vivo against L1210 murine leukemia. Compounds 9 and 12 showed antitumor activity higher than or comparable with that of tallimustine.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788096
Link To Document