Title of article
Derivatives of 5-amidine indole as inhibitors of thrombin catalytic activity
Author/Authors
Edwin J. Iwanowicz، نويسنده , , Wan F. Lau، نويسنده , , Ming-Ji James Lin، نويسنده , , Daniel G. M. Roberts، نويسنده , , Steven M. Seiler، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
6
From page
1339
To page
1344
Abstract
Substituted 5-amidine indoles were constructed based upon a computational analysis of putative modes of binding to thrombin utilizing coordinates from the crystal structure of BMS-183,507-α-thrombin complex. These analogs display competitive kinetics for the inhibition of human α-thrombin. The most potent member of this series 17, shows marked potency for thrombin with an inhibition constant, Ki of 260 nM.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788115
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