Title of article
Synthesis and evaluation of amino acid ester prodrugs of penciclovir
Author/Authors
Dae-Kee Kim، نويسنده , , Namkyu Lee، نويسنده , , Guang Jin Im، نويسنده , , Young Woo Kim، نويسنده , , Kieyoung Chang، نويسنده , , Hun-Taek Kim، نويسنده , , Yong-Baik Cho، نويسنده , , Won-Son Choi، نويسنده , , Inho Jung، نويسنده , , Key H. Kim، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
6
From page
1849
To page
1854
Abstract
The synthesis, aqueous solubility and stability, in vitro antiviral activity, and oral bioavailability of the amino acid ester prodrugs of penciclovir, 13–20, 23, and 24, are described. All of the prodrugs were highly soluble (>100 mg/mL) and sufficiently stable in aqueous solution. The oral bioavailability of (13) (34 %) in mice was comparable to that of famciclovir (33 %) and approximately 4-fold higher than that of penciclovir.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788214
Link To Document