Title of article
Studies on the structural feature of Sʹ1 subsite of neprilysin (EC.3.4.24.11): Stereochemical requirement for the enzyme-inhibitor docking process
Author/Authors
Denis Danvy، نويسنده , , Thierry Monteil، نويسنده , , Jean-Christophe Plaquevent، نويسنده , , Lucette Duhamel، نويسنده , , Pierre Duhamel، نويسنده , , Claude Gros، نويسنده , , Nadine Noël، نويسنده , , Jean Charles Schwartz، نويسنده , , Jeanne-Marie Lecomte، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
4
From page
2437
To page
2440
Abstract
The preferred conformation of thiorphan during the inhibitor-neprilysin docking process was investigated. A series of achiral inhibitors were tested. This study led to the design of a potent inhibitor, in which the ethylenic bond bears the aryl residue of P′1.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788371
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