Title of article
Studies on penam sulfones III. Synthesis and β-lactamase inhibitory activity of sodium (6R)-6-(α-hydroxybenzyl)-2β-methoxyiminomethyl-2α-methylpenam-3α-carboxylate 1,1-dioxide and sodium 2β-acyl-2α-methylpenam-3α-carboxylate 1,1-dioxide
Author/Authors
David P. Czajkowski، نويسنده , , Andhe V. N. Reddy، نويسنده , , Eduardo L. Setti، نويسنده , , Oludotun A. Phillips، نويسنده , , Ronald G. Micetich، نويسنده , , Chieko Kunugita، نويسنده , , Samarendra N. Maiti، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
4
From page
11
To page
14
Abstract
The synthesis and in vitro synergies of (6R)-6-(α-hydroxybenzyl)-2β-methoxyiminomethyl-2α-methylpenam-3α-carboxylate 1,1-dioxide (4) and 2β-acyl-2α-methylpenam-3α-carboxylate 1,1-dioxide (15) are described. Compound 15 showed good in vitro synergy in combination with piperacillin and ceftazidime against chromosomally mediated class I cephalosporinase producing organisms including TEM, SHV, and OXA-type enzymes producing microorganisms.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788499
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