Title of article
Imidazotriazinone inhibitors of the Ca2+-calmodulin sensitive phosphodiesterase (PDE I)
Author/Authors
Dennis J. Hlasta، نويسنده , , Donald C. Bode، نويسنده , , John J. Court، نويسنده , , Ranjit C. Desai، نويسنده , , Edward D. Pagani، نويسنده , , Paul J. Silver، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
89
To page
94
Abstract
Hybrid structural analogs 1 of the PDE V and PDE III inhibitors, zaprinast, milrinone, and CI-930 were prepared to identify dual PDE inhibitors. The SAR study led unexpectedly to the identification of WIN 61691 (8d), a potent inhibitor of PDE I (IC50 = 85 nM). A potent and selective inhibitor of PDE I would be a useful tool to elucidate the physiologic function of PDE I and other PDE isozymes in biological systems.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788516
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