Title of article
Cyclic saligenyl phosphotriesters of 2′,3′-dideoxy-2′,3′-didehydrothymidine (d4T) — a new pro-nucleotide approach
Author/Authors
Chris Meier، نويسنده , , Martina Lorey، نويسنده , , E. De Clercq، نويسنده , , Jan Balzarini، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
99
To page
104
Abstract
The synthesis of a new pro-nucleotide approach for d4TMP 2 based on cycloSal-d4TMP 3a-d is described. Phosphotriesters 3 release d4TMP 2 selectively by a controlled, chemically induced tandem reaction. CycloSal-phosphotriesters 3 exhibited high biological activity against HIV-1/HIV-2 in CEM cells which was retained in CEM TK− cells.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788518
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