Title of article
pH Dependence of the rate of DNA alkylation for (+)-duocarmycin SA and (+)-CCBI-TMI
Author/Authors
Dale L. Boger، نويسنده , , Christopher W. Boyce، نويسنده , , Douglas S. Johnson، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
233
To page
238
Abstract
A study of the DNA alkylation rate pH dependence with the establishment of pseudo first-order rate constants for 1 and 3 at a single high affinity site in w794 DNA is detailed. This dependence proved to be remarkably small with the rates increasing only 1.89x and 2.5x, respectively, over 2 pH units (pH 6–8).
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788545
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