Title of article
Regioselective synthesis of 3-aryl substituted pyrrolidines via palladium catalyzed arylation: pharmacological evaluation for central dopaminergic and serotonergic activity.
Author/Authors
Clas Sonesson، نويسنده , , H?kan Wikstr?m، نويسنده , , Martin W. Smith، نويسنده , , Kjell Svensson، نويسنده , , Arvid Carlsson، نويسنده , , Nicholas Waters، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
241
To page
246
Abstract
A series of 3-arylpyrrolidines has been synthesised via palladium catalyzed arylation and evaluated for dopaminergic and serotonergic activity in vitro and in vivo. Compounds substituted by electron withdrawing groups on the meta position of the aromatic ring, were found to be preferential dopamine autoreceptor antagonists.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788546
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