Title of article
New hetero-oligomeric peptide nucleic acids with improved binding properties to complementary DNA
Author/Authors
Stephan Jordan، نويسنده , , Christoph Schwemler، نويسنده , , Winfried Kosch، نويسنده , , Axel Kretschmer، نويسنده , , Udo Stropp، نويسنده , , Eckhardt Schwenner، نويسنده , , Burkhard Mielke، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
4
From page
687
To page
690
Abstract
Hetero-oligomeric PNAs consisting of new monomeric building blocks and various amounts of N-(2-aminoethyl) glycine have been synthesized by solid-phase chemistry. Some of these new compounds show stronger binding to complementary DNA than the original PNAs, and are consequently very interesting candidates as antisense compounds for applications in therapy and in diagnostics.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788633
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