Title of article
Sulfonopeptide inhibitors of leukocyte adhesion
Author/Authors
Kenneth G. Carson، نويسنده , , Charles F. Schwender، نويسنده , , Hitesh N. Shroff، نويسنده , , Nancy A. Cochran، نويسنده , , Debra L. Gallant، نويسنده , , Michael J. Briskin، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
4
From page
711
To page
714
Abstract
The amino acid sequence L-D-T-S-L has been shown to be a significant recognition motif involved in the interaction of integrin α4β7 with its endothelial ligand, MAdCAM-1. Based on the known active peptide, a series of sulfonamide peptidomimetics was synthesized. Sulfonopeptide 2, Ac-L-ψD-V-NH2, was shown to inhibit leukocyte adhesion.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788638
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