Title of article
Dicarboxylic acid inhibitors of phospholipase A2
Author/Authors
Dane M. Springer، نويسنده , , Bing-Yu Luh، نويسنده , , Stan V. DʹAndrea، نويسنده , , Joanne J. Bronson، نويسنده , , Muzammil M. Mansuri، نويسنده , , James R. Burke، نويسنده , , Kurt R. Gregor، نويسنده , , Paul L. Stanley، نويسنده , , Kenneth M. Tramposch، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
793
To page
798
Abstract
Ten diacids were synthesized via a simple regio- and stereoselective aldol reaction. All of these compounds were good to excellent inhibitors of 14 kDa human platelet PLA2, and many of these derivatives displayed activity in a phorbol-ester induced mouse ear edema assay. One of the new compounds reported here was selected for further development as a potential antipsoriasis agent.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788654
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