• Title of article

    Synthesis and inhibitory effect of a sialyl lewis X-acrylamide homopolymer at preventing cell adhesion

  • Author/Authors

    Hiroshi Miyauchi، نويسنده , , Masashi Tanaka، نويسنده , , Haruhiko Koike، نويسنده , , Nobuko Kawamura، نويسنده , , Masaji Hayashi، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 1997
  • Pages
    4
  • From page
    985
  • To page
    988
  • Abstract
    A novel glycopolymer, a homopolymer of conjugated SLeX-acrylamide, was synthesized and evaluated for its inhibitory activity against E-selectin mediated cell adhesion both in vitro and in vivo. The homopolymer showed approximately 10-fold higher activity per SLeX unit than the corresponding SLeX-acrylamide monomer in vitro and was significantly more effective in an LTA-induced murine pleurisy model.
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    1997
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    788691

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=788691