Title of article
The Gif system as a tool in medicinal chemistry: The oxidation of Sch 57726 under GoAggIII conditions
Author/Authors
Dar?o Doller، نويسنده , , Samuel Chackalamannil، نويسنده , , Andrew Stamford، نويسنده , , Brian McKittrick، نويسنده , , Michael Czarniecki، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
1381
To page
1386
Abstract
The usefulness of the GoAggIII reaction protocol in the determination of potential products of CP-450 enzyme metabolism is explored on Sch 57726, a selective c-GMP phosphodiesterase inhibitor. A single major ketone is found as product. In contrast, the reaction with m-CPBA affords a product of oxidative ring cleavage.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788774
Link To Document