Title of article
Cytotoxicity of bis(phenylamidinium)furan alkyl derivatives in human tumour cell lines: Relation to DNA minor groove binding
Author/Authors
Stephen Neidle، نويسنده , , L. R. Kelland، نويسنده , , J. O. Trent، نويسنده , , I. J. Simpson، نويسنده , , D. W. Boykin، نويسنده , , A. Kumar، نويسنده , , W. D. Wilson، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
1403
To page
1408
Abstract
A series of alkyl derivatives of bis(phenylamidinium)furan are shown to have cytotoxic activity in several human tumour cell lines. Xray crystallographic studies have previously shown that these compounds bind in the AT region of the DNA minor groove. It is suggested that activity is linked to this AT groove binding.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788778
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