Title of article
Inhibition of human rhinovirus 3C protease by homophthalimides
Author/Authors
Louis N. Jungheim، نويسنده , , Jeffrey D. Cohen، نويسنده , , Robert B. Johnson، نويسنده , , Elcira C. Villarreal، نويسنده , , Mark Wakulchik، نويسنده , , Richard J. Loncharich، نويسنده , , Q. May Wang، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
1589
To page
1594
Abstract
Homophthalimides 2a and 3a were found to be inhibitors of Rhinovirus 3C protease through a blind screening effort. SAR studies resulted in compound 3g, which exhibited improved enzyme inhibition, in addition to whole cell antiviral activity. Molecular modeling studies suggest a preferred enzyme/inhibitor interaction, and LC/MS experiments confirmed tight/covalent binding of 3g to the enzyme.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788815
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