Title of article
Benzothiazol-2-ylcarboxylic acids with diverse spacers: A novel class of potent, orally active aldose reductase inhibitors
Author/Authors
Tomoji Aotsuka، نويسنده , , Naoki Abe، نويسنده , , Kanako Fukushima، نويسنده , , Naoki Ashizawa، نويسنده , , Motoyuki Yoshida، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
1677
To page
1682
Abstract
The benzothiazol-2-ylcarboxylic acids, with diverse spacers between the carboxy group and the benzothiazole ring, were synthesized and evaluated for their ability to inhibit aldose reductase (AR). The phenylacetic acids 6 which have a less complex structure than that of existing AR inhibitors were found to be highly potent, orally active AR inhibitors.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788831
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