Title of article
Conformationally restricted arginine analogues as inhibitors of human nitric oxide synthase
Author/Authors
Barry G. Shearer، نويسنده , , Shuliang Lee، نويسنده , , Karl W. Franzmann، نويسنده , , Helen A. R. White، نويسنده , , Daniella C. J. Sanders، نويسنده , , Rachel J. Kiff، نويسنده , , Edward P. Garvey، نويسنده , , Eric S. Furfine، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
1763
To page
1768
Abstract
Conformationally restricted analogues of the endogenous NOS substrate -arginine and the arginine based NOS inhibitors NG-methyl- -arginine ( -NMA) and Nδ-iminoethyl- -ornithine ( -NIO) were synthesized for evaluation as inhibitors of human NOS. Incorporation of a phenyl ring into the C4---C5 backbone chain provided 2-aminophenylalanine analogues which retained potent NOS inhibition. Structurally related analogues of 3-aminophenylalanine were significantly weaker inhibitors.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788849
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