Title of article
Novel A-ring cleaved analogs of oleanolic and ursolic acids which affect growth regulation in NRP.152 prostate cells
Author/Authors
Heather J. Finlay، نويسنده , , Tadashi Honda، نويسنده , , Gordon W. Gribble، نويسنده , , David Danielpour، نويسنده , , Nicole E. Benoit، نويسنده , , Nanjoo Suh، نويسنده , , Charlotte Williams، نويسنده , , Michael B. Sporn، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
4
From page
1769
To page
1772
Abstract
Syntheses of eight novel A-ring cleaved oleanane and ursane analogs are described. These compounds were assessed for their ability to inhibit cell proliferation in NRP.152 prostate cells. Four A-ring cleaved derivatives showed significant activity; 5β-(1-methyl-2-ethyl)-10α-(3-aminopropyl)-des-A-urs-12-en-28-oic acid was the most active compound, (IC50, 0.3μM).
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788850
Link To Document