Title of article
Molecular modeling of the interaction of trypanocide guanyl hydrazones with B-DNA
Author/Authors
Osvaldo A. Santos-Filho، نويسنده , , J. Daniel Figueroa-Villar، نويسنده , , Martha T. Araujo، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
1797
To page
1802
Abstract
Molecular modeling of the interaction of trypanocide aromatic guanyl hydrazones with B-DNA showed that the preferential sites for interaction are the DNA minor groove AT rich regions, with hydrogen bonding between the guanidine moiety of the drugs and the thymine O2, and the adenine N3. There is a correlation between the total interaction energy and ID50.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788855
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