Title of article
Structure-activity relationship of cantharidin derivatives to protein phosphatases 1, 2A1, and 2B
Author/Authors
Mikiko Sodeoka، نويسنده , , Yoshiyasu Baba، نويسنده , , Satoko Kobayashi، نويسنده , , Nozomu Hirukawa، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
4
From page
1833
To page
1836
Abstract
The effects of structural modification of cantharidin on the inhibition of protein Ser/Thr phosphatases are described. Removal of the methyl substituents at C2 and C3 in cantharidin improved the inhibition of PP2B. In contrast, introduction of a substituent to C1/C4-position drastically decreased inhibition of PP1 and PP2A1. PP2B was found to be quite tolerant to modifications at the C5 position.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788862
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