Title of article
Trypanocidal activity and redox potential of heterocyclic- and 2-hydroxy-naphthoquinones
Author/Authors
Mar?lia O. F. Goulart، نويسنده , , Carlos L. Zani، نويسنده , , Josealdo Tonholo، نويسنده , , Luciano R. Freitas، نويسنده , , Fabiane C. de Abreu، نويسنده , , Ala?de B. Oliveira، نويسنده , , Délio S. Raslan، نويسنده , , Sérgia Starling، نويسنده , , Egler Chiari، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
2043
To page
2048
Abstract
With the aim of understanding the influence of redox potentials on the trypanocidal activity, a series of quinones were tested in vitro with trypomastigotes of Trypanosoma cruzi and their first cathodic potentials (Epcl) measured by cyclic voltammetry. All quinones with Epcl> −0.72V were active, while most of those with Epcl< −0.72V were inactive, suggesting a contribution of the easiness of reduction on the biological activity.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788902
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