Title of article
Novel hydroxyphosphonate inhibitors of CD-45 tyrosine phosphatase
Author/Authors
Roger F. Frechette، نويسنده , , Caridad Ackerman، نويسنده , , Scott Beers، نويسنده , , Rich Look، نويسنده , , John Moore، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
4
From page
2169
To page
2172
Abstract
CD-45 tyrosine phosphatase [E.C. 3.1.3.48] is an important player in the regulation of cell activation and proliferation in hematopoetic cells. As part of a program in immune response modulation, we prepared the first series of small organic molecule inhibitors of CD-45. The preparation and in vitro screening of these hydroxyphosphonates is described herein.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788927
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