Title of article
Catalysis of the Kemp elimination by antibodies elicited against a cationic hapten
Author/Authors
Arnaud Genre-Grandpierre، نويسنده , , Daniel R. Talham and Charles Tellier، نويسنده , , Marie-Jeanne Loirat، نويسنده , , Dominique Blanchard، نويسنده , , David R. W. Hodgson، نويسنده , , Florian Hollfelder، نويسنده , , Anthony J. Kirby، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
2497
To page
2502
Abstract
Rather efficient catalysis of the decomposition of 5-nitro-benzisoxazole to the cyanophenol was observed with antibodies elicited against a cationic hapten structurally unrelated to the benzisoxazole substrate. The rate enhancement by the most active antibody is better than 104 and the reaction is catalyzed by a carboxylate group associated with a hydrophobic binding site.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788990
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