Title of article
Acetylcholinesterase inhibition by tacrine analogues
Author/Authors
Piero Valenti، نويسنده , , Angela Rampa، نويسنده , , Alessandra Bisi، نويسنده , , Vincenza Andrisano، نويسنده , , Vanni Cavrini، نويسنده , , Lorena Fin، نويسنده , , Alessandro Buriani، نويسنده , , Piero Giusti، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
4
From page
2599
To page
2602
Abstract
Analogues of tacrine were synthesized and evaluated for acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitory activity. Compound 2a was the most potent inhibitor of AChE with a higher selectivity than tacrine for AChE over BuChE. Tacrine, on the other hand, showed the opposite behaviour with a weaker inhibitory effect on AChE than on BuChe. The compounds displayed correlated activities in isolated enzymes as well as in rat brain homogenates.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789010
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