Title of article
Epidermal growth factor receptor tyrosine kinase: Structure-activity relationships and antitumour activity of novel quinazolines
Author/Authors
K. H. Gibson، نويسنده , , W Grundy، نويسنده , , A. A. Godfrey، نويسنده , , J. R. Woodburn، نويسنده , , S. E. Ashton، نويسنده , , B. J. Curry، نويسنده , , L Scarlett، نويسنده , , A. J. Barker، نويسنده , , D. S. Brown، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
2723
To page
2728
Abstract
Investigation of structure-activity relationships of novel quinazolines has identified a 4-(4-iso-quinolylamino)-quinazoline and a 4-(trans-2-phenylcyclopropylamino)-quinazoline as potent inhibitors of EGF-receptor tyrosine kinase in vitro. Further modifications of the latter compound have identified a derivative which shows anti-tumour activity against a tumour xenograft model when dosed orally once per day.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789035
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