Title of article
A novel photoaffinity label for the dopamine transporter based on N-substituted 3α-[bis(4′-fluorophenyl)methoxy]tropane
Author/Authors
Gregory E. Agoston، نويسنده , , Roxanne Vaughan، نويسنده , , John R. Lever، نويسنده , , Sari Izenwasser، نويسنده , , Phyllis D. Terry، نويسنده , , Amy Hauck Newman، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
3027
To page
3032
Abstract
A novel photoaffinity label for the dopamine transporter (DAT) based on N-substituted 3α-[bis(4′-fluorophenyl)methoxy]tropane has been synthesized in five steps and has been characterized. Preliminary binding studies indicated this ligand bound irreversibly to the dopamine transporter. Preparation of the 125I analog and its photoactivation in the presence of membrane bound DAT demonstrated it covalently binds to the DAT.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789093
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