Title of article
Synthesis and cell growth inhibitory properties of substituted (E)-1-phenylbut-1-en-3-ones
Author/Authors
Sylvie Ducki، نويسنده , , John A. Hadfield، نويسنده , , Lucy A. Hepworth، نويسنده , , Nicholas J. Lawrence، نويسنده , , Ching-Ying Liu، نويسنده , , Alan T. McGown، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
4
From page
3091
To page
3094
Abstract
A series of (E)-1-phenylbut-1-en-3-ones, based on the naturally occurring (E)-1-(4′-hydroxyphenyl)but-1-en-3-one [IC50 (K562) 60 μM], was synthesised and screened for cytotoxic activity against the K562 human leukaemia cell line. (E)-1-(Pentafluorophenyl)but-1-en-3-one [IC50 (K562) 1.8 μM] was found to be over 30-fold more active than 1.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789105
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