Title of article
Synthesis of 4-trifluoromethylsteroids: A novel class of steroid 5α-reductase inhibitors
Author/Authors
Xiang-Shu Fei، نويسنده , , Wei-Sheng Tian، نويسنده , , Qing-Yun Chen، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
3113
To page
3118
Abstract
A concise synthetic approach to 4-trifluoromethyl steroids, a novel class of steroid 5α-reductase inhibitors, is described. Direct trifluoromethylation of steroid olefinic bromide with methyl fluorosulfonyl-difluoroacetate was used as a key step in the synthesis. The compound 4 exhibited highly inhibitory activity than Finasteride in in vitro assay.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789109
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