Title of article
Novel water-soluble analogues retaining potent antitumor activity of RA-VII, a cyclic hexapeptide from Rubia plants
Author/Authors
Yukio Hitotsuyanagi، نويسنده , , Yoshiaki Anazawa، نويسنده , , Takehiro Yamagishi، نويسنده , , Kazunori Samata، نويسنده , , Tomoko Ichihara، نويسنده , , Kayoko Nanaumi، نويسنده , , Noriko Okado، نويسنده , , Shiro Nakaike، نويسنده , , Mariko Mizumura، نويسنده , , Koichi Takeya، نويسنده , , Hideji Itokawa، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
4
From page
3125
To page
3128
Abstract
Deoxybouvardin (3) was reacted with 2-dialkylaminoethyl chloride salts to produce analogues 4a-h. All analogues retained antitumor activity against P388 leukemia in mice, and analogue 4c showed more promising antitumor activity than RA-VII (1) against the P388 leukemia, B16 melanoma and colon adenocarcinoma 26 murine tumor models. The hydrochloride salt of 4c is soluble in water.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789111
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