Title of article
Synthesis, DNA-damaging and cytotoxic properties of novel topoisomerase II-directed bisantrene analogues
Author/Authors
Giuseppe Zagotto، نويسنده , , Ambrogio Oliva، نويسنده , , Fulvio Guano، نويسنده , , Ernesto Menta، نويسنده , , Giovanni Capranico، نويسنده , , Manlio Palumbo، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
121
To page
126
Abstract
New bisantrene analogues were synthesized, bearing one or two 4,5-dihydro-1H-imidazol-2-yl hydrazone side chains at positions 1,4 or 9 of the anthracene ring system. A 10-azabioisostere was also prepared. The position of substituents in structurally isomeric drugs modulates topoisomerase II poisoning and specificity, along with cytotoxicity.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789191
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