Title of article
Quaternary substituted PDE4 inhibitors I: The synthesis and in vitro evaluation of a novel series of oxindoles
Author/Authors
Christopher Hulme، نويسنده , , Gregory B. Poli، نويسنده , , Fu-Chih Huang، نويسنده , , John E. Souness، نويسنده , , Stevan W. Djuric، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
4
From page
175
To page
178
Abstract
The following letter presents the synthesis and in vitro evaluation of a novel quaternary substituted series of phosphodiesterase type (IV) (PDE4) inhibitors. The compounds represent conformationally constrained analogues of the Celltech PDE IV inhibitor, CDP 840. Examples with sub-micromolar IC50ʹs for PDE4 inhibition are reported.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789202
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