Title of article
Quaternary substituted PDE IV inhibitors II: The synthesis and in vitro evaluation of a novel series of γ-lactams
Author/Authors
Christopher Hulme، نويسنده , , Kevin Moriarty، نويسنده , , Fu-Chih Huang، نويسنده , , Jonathon Mason، نويسنده , , Dan McGarry، نويسنده , , Richard Labaudiniere، نويسنده , , John Souness، نويسنده , , Stevan Djuric، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
399
To page
404
Abstract
This communication describes the synthesis and in vitro evaluation of a novel potent series of phosphodiesterase type (IV) (PDE IV) inhibitors. Several of the quaternary substituted lactams presented possess low nanomolar IC50ʹs for PDE IV inhibition.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789249
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