Title of article
Structure-activity relationships of a series of 1-substituted-4-methylbenzimidazole neuropeptide Y-1 receptor antagonists
Author/Authors
Dennis M. Zimmerman، نويسنده , , Buddy E. Cantrell، نويسنده , , Edward C. R. Smith، نويسنده , , James A. Nixon، نويسنده , , Robert F. Bruns، نويسنده , , Bruce Gitter، نويسنده , , Philip A. Hipskind، نويسنده , , Paul L. Ornstein، نويسنده , , Hamideh Zarrinmayeh، نويسنده , , Thomas C. Britton، نويسنده , , Douglas A. Schober، نويسنده , , Donald R. Gehlert، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
4
From page
473
To page
476
Abstract
The characterization of a novel series of NPY-1 receptor antagonists derived from the 4-methylbenzimidazole 4 is described. Appropriate substitution on the piperidyl nitrogen of 4 led to systematic increases in Y-1 receptor affinity, to approximately 50-fold, and to the discovery of the importance of a second basic substituent.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789264
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