Title of article
Synthesis of a potent wide-spectrum serotonin-, norepinephrine-, dopamine-reuptake inhibitor (SNDRI) and a species-selective dopamine-reuptake inhibitor based on the gamma-amino alcohol functional group
Author/Authors
Paul R. Carlier، نويسنده , , Michael M-C. Lo، نويسنده , , Priscilla C-K. Lo، نويسنده , , Elliott Richelson، نويسنده , , Masahiko Tatsumi، نويسنده , , Ian J. Reynolds، نويسنده , , Terre A. Sharma، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
487
To page
492
Abstract
A series of gamma-amino alcohols were synthesized and screened for reuptake inhibition and noncompetitive NMDA antagonism. Compound (±)-3f simultaneously and potently inhibits reuptake of 5-HT, NE, and DA, representing a potential wide-spectrum reuptake inhibitor antidepressant. In addition, comparative rat and human studies uncovered a species-selective DA reuptake inhibitor (±)-2e, .
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789267
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