Title of article
Indolequinone antitumor agents: Relationship between quinone structure and rate of metabolism by recombinant human NQO1
Author/Authors
Howard D. Beall، نويسنده , , Anna R. Hudnott، نويسنده , , Shannon Winski، نويسنده , , David Siegel، نويسنده , , Elizabeth Swann، نويسنده , , David Ross، نويسنده , , Christopher J. Moody، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
4
From page
545
To page
548
Abstract
A series of indolequinones bearing various functional groups has been synthesized, and the effects of substituents on the metabolism of the quinones by recombinant human NAD(P)H:quinone oxidoreductase (NQO1), and on the toxicity toward nonsmall cell lung cancer cells with either high NQO1 activity (H460) or with no detectable activity (H596) were studied.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789278
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