Title of article
Toward the antibody-catalyzed chemiluminescence. Design and synthesis of hapten
Author/Authors
Masaaki Sawa، نويسنده , , Yasuhiro Imaeda، نويسنده , , Jun Hiratake، نويسنده , , Ryota Fujii، نويسنده , , Ritsuko Umeshita، نويسنده , , Mitsuo Watanabe، نويسنده , , Hitoshi Kondo، نويسنده , , Junichi Oda، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
647
To page
652
Abstract
Hapten 4 was synthesized to generate catalytic antibodies triggering chemiluminescence by catalyzing the decomposition of the 1,2-dioxetane 3. The hapten 4 was so designed as to elicit a negatively charged functional group in the antibody combining site to catalyze the β-elimination of the protecting group in 3 as well as to lock the protecting group into an energetically favorable anti-periplanar conformation.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789297
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