Title of article
Endothiopeptide inhibitors of HIV-1 protease
Author/Authors
Shao Yao، نويسنده , , Reena Zutshi، نويسنده , , Jean Chmielewski، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
699
To page
704
Abstract
Endothiopeptide inhibitors of HIV-1 protease were synthesized by chemical and enzymatic methods to individually replace each backbone amide bond in 1 with a thioamide-linkage. Interestingly, agent 7, which contains a thioamide-linkage between the P2′ and P3′ positions of 1, was the most potent, competitive inhibitor of HIV-1 protease with a Ki of 3.4 μM.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789307
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