Title of article
Tripeptide growth hormone secretagogues
Author/Authors
Lihu Yang، نويسنده , , Greg Morriello، نويسنده , , Yanping Pan، نويسنده , , Ravi P. Nargund، نويسنده , , Khaled Barakat، نويسنده , , Kristine Prendergast، نويسنده , , Kang Cheng، نويسنده , , Wanda W. -S. Chan، نويسنده , , Roy G. Smith، نويسنده , , Arthur A. Patchett، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
759
To page
764
Abstract
A series of C-terminus capped dipeptides and tripeptides was synthesized as growth hormone (GH) secretagogues. Among them, tripeptide Aib-D-Trp-D-homoPhe-OEt showed low nanomolar activity in the rat pituitary assay. Thus, we have demonstrated that the GH secretagogue activity of the hexa- hepta-GH releasing peptides can be mimicked at the tripeptide level.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789319
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