Title of article
Identification of a non peptidic RANTES antagonist
Author/Authors
Colin Bright، نويسنده , , Thomas J. Brown، نويسنده , , Paul Cox، نويسنده , , Frank Halley، نويسنده , , Peter Lockey، نويسنده , , Iain M. McLay، نويسنده , , Una Moore، نويسنده , , Barry Porter، نويسنده , , Robert J. Williams، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
4
From page
771
To page
774
Abstract
A series of phenothiazines demonstrating inhibition of RANTES binding to THP-1 cell membranes has been identified. The lead compound RP23618 (IC50=3μM) was found to inhibit specific binding of 125I-RANTES, but not 125I-MCP-1 to THP-1 cell membranes and furthermore to antagonise RANTES, but not MCP-1-induced chemotaxis of THP-1 cells
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789321
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