Title of article
Organometallic photonucleases: A novel class of DNA-cleaving agents
Author/Authors
Debra L. Mohler، نويسنده , , David R. Dain، نويسنده , , Angela D. Kerekes، نويسنده , , William R. Nadler، نويسنده , , Tricia L. Scott، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
4
From page
871
To page
874
Abstract
The first demonstration of DNA cleavage by an organic radical generated via homolysis of a metalalkyl bond in a Cp-metal complex is presented. Irradiation of CpW(CO)3CH3 (1.5 molecules/base pair) produced methyl radical, giving single-strand cleavage of pBR322 DNA. This process was inhibited by the general radical trap cysteine and by TEMPO, which traps carbon radicals but not oxygen-centered radicals.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789339
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