Title of article
Synthesis and antitumor activity of leinamycin derivatives: Modifications of C-8 hydroxy and C-9 keto groups
Author/Authors
Yutaka Kanda، نويسنده , , Tadashi Ashizawa، نويسنده , , Yutaka Saitoh، نويسنده , , Hiromitsu Saito، نويسنده , , Katsushige Gomi، نويسنده , , Masami Okabe، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
4
From page
909
To page
912
Abstract
A series of leinamycin derivatives were synthesized and evaluated for antitumor activity. Modifications at C-8 and C-9 positions revealed a broad structure-activity relationship in vitro and some derivatives showed potent antiproliferative activity against HeLa S3 cells.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789346
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