Title of article
Potent antimitotic and cell growth inhibitory properties of substituted chalcones
Author/Authors
Sylvie Ducki، نويسنده , , Richard Forrest، نويسنده , , John A. Hadfield، نويسنده , , Alex Kendall، نويسنده , , Nicholas J. Lawrence، نويسنده , , Alan T. McGown، نويسنده , , David Rennison، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
1051
To page
1056
Abstract
A series of substituted chalcones was synthesised and screened for cytotoxic activity against the K562 human leukaemia cell line. (E)-3-(3″-Hydroxy-4″-methoxyphenyl)-2-methyl-1-(3′,4′,5′-trimethoxyphenyl)-prop-2-en-1-one [IC50 (K562) 0.21 nM] was found to be the most active. A relationship between the conformation and cytotoxicity of the chalcones is discussed.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789374
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