Title of article
Synthesis and hypoxia-selective cytotoxicity of a 2-nitroimidazole mustard
Author/Authors
John H. H. Lee، نويسنده , , B. D. Palmer، نويسنده , , W. R. Wilson، نويسنده , , W. A. Denny، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
4
From page
1741
To page
1744
Abstract
A four-step synthesis of 5-[N,N-bis(2-chloroethyl)amino]-1-methyl-2-nitroimidazole from 1-methyl-2-nitroimidazole is described. This compound showed similar hypoxia-selective cytotoxicity to the dinitrobenzamide mustard SN 23862 in UV4 cells (ca. 40-fold), and superior selectivity (>7-fold) in repaircompetent AA8 cells.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789508
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