Title of article
A practical synthesis of 3-substituted Δ3,5(6)-Steroids as new potential 5α-reductase inhibitor
Author/Authors
Weisheng Tian، نويسنده , , Zheng-Zhu Li and Y. S. Tsai ، نويسنده , , Qingjiang Liao، نويسنده , , Yikang Wu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
4
From page
1949
To page
1952
Abstract
A new and practical synthetic approach to 3-substituted Δ3,5(6)-Steroids, as potential 5α-reductase inhibitor, is described. The key step involves Pd-catalyzed coupling reaction of steroid 3-enol 5H-3-oxo-octafluoropentanosulfonates. 3-Phenylacetylenyl substituted Δ3,5(6)-steroid 3g and 3-phosphate substituted Δ3,5(6)-steroid 3f in our synthesized compounds exhibited high 5α-reductase inhibitory activity in vitro assay.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789549
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