Title of article
Hantzsch pyrrole synthesis on solid support
Author/Authors
Axel W. Trautwein، نويسنده , , Roderich D. Sü?muth، نويسنده , , Günther Jung، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
4
From page
2381
To page
2384
Abstract
An efficient method for solid-phase synthesis of pyrroles is described. Polystyrene Rink amide resin is acetoacetylated and converted into polymer bound enaminones upon treatment with primery amines. These then undergo a Hantzsch reaction with α-bromoketones to yield pyrroles. After cleavage with 20% trifluoroacetic acid in dichloromethane pyrrole-3-carboxamides are obtained in excellent purity.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789629
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